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Showing 1–5 of 5 results
Advanced filters: Author: Sandip A. Shelke Clear advanced filters

  • An RNA enzyme has been generated that can assemble a mirror-image version of itself. The finding helps to answer a long-standing conundrum about how RNA molecules could have proliferated on prebiotic Earth. See Letter p.440

    • Sandip A. Shelke
    • Joseph A. Piccirilli
    News & Views
    Nature
    Volume: 515, P: 347-348

  • The high-resolution crystal structures of apo and self-alkylated ribozymes demonstrate the structural and biochemical basis of carbon–nitrogen bond formation between a specific guanine within the ribozyme and a 2,3-disubstituted epoxide substrate.

    • Daniel Krochmal
    • Yaming Shao
    • Joseph A. Piccirilli
    Research
    Nature Chemical Biology
    Volume: 18, P: 376-384

  • Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional homology among different types of picornaviral IRESs is structure-based.

    • Deepak Koirala
    • Yaming Shao
    • Joseph A. Piccirilli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Spinach is an RNA aptamer analog of GFP that is widely used for fluorescent labeling of cellular RNAs. Crystal structures of Spinach–fluorophore complexes uncover an unusual G-quadruplex RNA fold that is involved in ligand recognition and tuning of Spinach fluorescence properties.

    • Hao Huang
    • Nikolai B Suslov
    • Joseph A Piccirilli
    Research
    Nature Chemical Biology
    Volume: 10, P: 686-691