The human genome contains approximately 800 G proteincoupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, the authors show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemical properties.
- Emily P. Hardy
- A. Nasim Haider
- Leonidas Tsiokas
