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Showing 1–6 of 6 results
Advanced filters: Author: Sandra Jeudy Clear advanced filters

  • DNA methylation is an epigenetic marker in all domains of life. Here, Jeudy et al., using single-molecule realtime sequencing, determine DNA methylation patterns in giant viruses and evolutionary analysis of virus encoded DNA methyltransferases suggests that they affect viral fitness.

    • Sandra Jeudy
    • Sofia Rigou
    • Matthieu Legendre
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Large dsDNA viruses either replicate in or disrupt the nucleus to gain access to host RNA polymerases, or they rely on virus-encoded, packaged RNA polymerases. Here, the authors show that Noumeavirus replicates in the cytoplasm and relies on a transient recruitment of nuclear proteins to initiate replication.

    • Elisabeth Fabre
    • Sandra Jeudy
    • Chantal Abergel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Until today, genetic tools have been lacking to enable manipulation of amoebal giant viruses (GVs) by CRISPR/Cas9 technology. Here, Bisio et al. apply S. pyogenes Cas9 together with pU6- driven guide RNAs to investigate the replication of pandoravirus, a GV replication in the nucleus. Using this tool, they provide evidence for stepwise evolution and genetic expansion of viral gigantism.

    • Hugo Bisio
    • Matthieu Legendre
    • Chantal Abergel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Giant viruses are visible by light microscopy and have unusually long genomes. Here, the authors report three new members of the Pandoraviridae family and investigate their evolution and diversity.

    • Matthieu Legendre
    • Elisabeth Fabre
    • Jean-Michel Claverie
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12