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Showing 1–7 of 7 results
Advanced filters: Author: Sandra L Halverson Clear advanced filters

  • Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

    • Stig E Bojesen
    • Karen A Pooley
    • Alison M Dunning
    Research
    Nature Genetics
    Volume: 45, P: 371-384

  • GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.

    • Babatunde Adedokun
    • Zhaohui Du
    • Dezheng Huo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls, followed by genotyping using the iCOGS array in an additional 52,675 cases and 49,436 controls from studies within the Breast Cancer Association Consortium (BCAC). They identify 41 loci newly associated with susceptibility to breast cancer.

    • Kyriaki Michailidou
    • Per Hall
    • Douglas F Easton
    Research
    Nature Genetics
    Volume: 45, P: 353-361

  • Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

    • Montserrat Garcia-Closas
    • Fergus J Couch
    • Peter Kraft
    Research
    Nature Genetics
    Volume: 45, P: 392-398

  • Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A.

    • Keri L Monda
    • Gary K Chen
    • Christopher A Haiman
    Research
    Nature Genetics
    Volume: 45, P: 690-696