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Showing 1–2 of 2 results
Advanced filters: Author: Sandra Pérez-Ramos Clear advanced filters

  • Chimeric antigen receptor T (CAR-T) cell therapy is efficient in certain haematologic malignancies, but clinical success in solid tumours has been hampered by scarcity of tumour-specific antigens. Here authors show that combination therapy using CAR T cells targeting p95HER2 and bispecific antibodies against HER2 and CD3 consistently leads to complete regression in HER2-positive, patient-derived xenografts tumours in mouse models.

    • Macarena Román Alonso
    • Ariadna Grinyó-Escuer
    • Joaquín Arribas
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Chaib et al. find that therapy-induced senescent cells have high programmed cell death 1 ligand 2 (PD-L2), contributing to recurrence. They show that PD-L2 blocking combined with chemotherapy is therapeutically beneficial because it reduces senescent cells and immunosuppressive cell recruitment.

    • Selim Chaib
    • José Alberto López-Domínguez
    • Manuel Serrano
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 448-462