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Showing 1–7 of 7 results
Advanced filters: Author: Sandra Schüler Clear advanced filters

  • Researchers found that a plant U1 snRNP complex associates with 200 proteins and conducts splicing-independent roles by safeguarding RNAs against premature cleavage and polyadenylation, similar to a process known as telescripting in metazoans.

    • Anchilie F. Mangilet
    • Joachim Weber
    • Sascha Laubinger
    ResearchOpen Access
    Nature Plants
    Volume: 10, P: 1514-1531

  • Non-coding introns are excised from RNA transcripts of most eukaryotic genes by splicing. Here, Kenny et al. show that LUC7 proteins promote the splicing of different subsets of introns with distinct 5′ splice site sequences, and that these preferences are conserved from plants to human.

    • Connor J. Kenny
    • Michael P. McGurk
    • Christopher B. Burge
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

    • Cosimo Posth
    • He Yu
    • Johannes Krause
    ResearchOpen Access
    Nature
    Volume: 615, P: 117-126

  • In a large single-arm phase 2 trial, the anti-PD-1 inhibitor tislelizumab combined with the next-generation BTK inhibitor zanubrutinib had an overall response rate of 58.3% and was well tolerated in patients with Richter’s transformation.

    • Othman Al-Sawaf
    • Rudy Ligtvoet
    • Barbara Eichhorst
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 240-248

  • Analysis of genotyping-by-sequencing data for more than 20,000 barley accessions from a German genebank provides a framework for genomics-assisted genebank management and analysis of large germplasm collections for important crops.

    • Sara G. Milner
    • Matthias Jost
    • Nils Stein
    Research
    Nature Genetics
    Volume: 51, P: 319-326

  • Here, the authors show that IFNγ binding to heparan sulfate is a mechanism to restrain IFNγ at the site of production, thereby preventing high systemic levels of this cytokine and associated immunopathology.

    • Josephine Kemna
    • Evelyne Gout
    • Thomas Blankenstein
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 414-422