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Advanced filters: Author: Sandy Schamus Clear advanced filters

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

DNA repair is crucial to maintain cellular genome stability and integrity. Here, the authors show that XRCC1 and DNA polymerase β, two essential proteins in DNA repair, heterodimerize to protect the latter from proteasome degradation.

Qingming Fang
Burcu Inanc
Robert W. Sobol
Research26 Nov 2014
Nature Communications

Volume: 5, P: 1-16
ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.

Tatiana Moiseeva
Brian Hood
Christopher J. Bakkenist
ResearchOpen Access09 Nov 2017
Nature Communications

Volume: 8, P: 1-11
Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

Frank P. Vendetti
Brian J. Leibowitz
Christopher J. Bakkenist
ResearchOpen Access01 Feb 2017
Scientific Reports

Volume: 7, P: 1-12