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Showing 1–3 of 3 results
Advanced filters: Author: Sanja Pajovic Clear advanced filters

  • Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.

    • Sanja Pajovic
    • Robert Siddaway
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers compared to mutation rate as an alternative mechanism for activation of oncogenic pathways such as RAS/MAPK.

    • Robert Siddaway
    • Scott Milos
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14