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Showing 1–7 of 7 results
Advanced filters: Author: Sanjay H. Chotirmall Clear advanced filters

  • Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.

    • Louisa L. Y. Chan
    • Danielle E. Anderson
    • Sanjay H. Chotirmall
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Toll-like receptor 7 (TLR7) normally recognizes exogenous single-stranded RNA for the activation of innate immunity. Here the authors show that TLR7 may also contribute, via the modulation of mast cell functions, to experimental, cigarette smoke-induced mouse models of emphysema, thereby hinting TLR7 as a potential therapeutic target for human lung inflammation.

    • Gang Liu
    • Tatt Jhong Haw
    • Philip M. Hansbro
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24

  • The roles of extracellular RNAs present in bacterial biofilms are poorly understood. Here, Mugunthan et al. show that specific mRNAs associate with extracellular DNA in the matrix of bacterial biofilms, facilitating the formation of viscoelastic networks.

    • Sudarsan Mugunthan
    • Lan Li Wong
    • Thomas Seviour
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Integrated analysis of bacterial, fungal and microbial communities in the airways of patients with bronchiectasis demonstrates that interaction networks, rather than the relative abundance of any single microbial species, are associated with exacerbation risk.

    • Micheál Mac Aogáin
    • Jayanth Kumar Narayana
    • Sanjay H. Chotirmall
    Research
    Nature Medicine
    Volume: 27, P: 688-699

  • Whole-genome sequencing and population genomics of 218 Aspergillus fumigatus environmental and clinical isolates reveals strong genetic clustering and the occurrences of near-identical genotypes, indicating the infection of patients with resistant isolates from the environment.

    • Johanna Rhodes
    • Alireza Abdolrasouli
    • Matthew C. Fisher
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 663-674

  • Bronchiectasis refers to dilatation in the bronchi, as detected by radiological examination. Often the result of other diseases, bronchiectasis is also a disease in its own right and can lead to chronic infections, inflammation, airway damage and, ultimately, reduced lung function and respiratory failure.

    • James D. Chalmers
    • Anne B. Chang
    • Pamela J. McShane
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-18