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Showing 1–11 of 11 results
Advanced filters: Author: Sanket Patel Clear advanced filters

  • Longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period shows that microbes acquired from cow microbiomes introduce clinically relevant antimicrobial resistance genes to farmer guts.

    • Bejan Mahmud
    • Rhiannon C. Vargas
    • Gautam Dantas
    Research
    Nature Microbiology
    Volume: 9, P: 1007-1020

  • The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform.

    • Anuj Khandelwal
    • Caitlin N. Kent
    • Brian S. J. Blagg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Here, the authors characterize the microbiome and resistome in a longitudinal cohort of 159 international students visiting the Andean city of Cusco, Peru. They find that international travel associates with spread of antimicrobial resistance, and that travelers’ diarrhea increases a persons’ risk for acquiring antimicrobial-resistant pathogens, while a diverse, “healthy” microbiome can be protective against diarrhea.

    • Manish Boolchandani
    • Kevin S. Blake
    • Gautam Dantas
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The authors investigate the burden and spatiotemporal dynamics of multidrug-resistant bacteria on intensive care unit surfaces from two hospitals in the US and Pakistan over a year. They find Acinetobacter baumannii and Enterococcus faecium co-association, likely due to synergistic biofilm formation.

    • Alaric W. D’Souza
    • Robert F. Potter
    • Gautam Dantas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Functional metagenomic selections for resistance to 18 antibiotics in 18 different soils reveal that bacterial community composition is the primary determinant of soil antibiotic resistance gene content.

    • Kevin J. Forsberg
    • Sanket Patel
    • Gautam Dantas
    Research
    Nature
    Volume: 509, P: 612-616

  • An analysis of bacterial community structure and antibiotic resistance gene content of interconnected human faecal and environmental samples from two low-income communities in Latin America was carried out using a combination of functional metagenomics, 16S sequencing and shotgun sequencing; resistomes across habitats are generally structured along ecological gradients, but key resistance genes can cross these boundaries, and the authors assessed the usefulness of excreta management protocols in the prevention of resistance gene dissemination.

    • Erica C. Pehrsson
    • Pablo Tsukayama
    • Gautam Dantas
    Research
    Nature
    Volume: 533, P: 212-216

  • Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

    • Nikolay S. Markov
    • Ziyou Ren
    • Brian White
    Research
    Nature Immunology
    Volume: 25, P: 1607-1622

  • Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

    • Rogan A. Grant
    • Luisa Morales-Nebreda
    • Ziyou Ren
    Research
    Nature
    Volume: 590, P: 635-641