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Showing 1–8 of 8 results
Advanced filters: Author: Santosh Adhikari Clear advanced filters

  • Dynamic gene expression is crucial for coordinating diverse cellular activities, but challenging to modulate with high spatiotemporal precision. Now, a photoswitchable DNA structure-specific, small-molecule ligand enables reversible, light-controlled regulation of gene expression and cell proliferation in live cells.

    • Xiaoyun Zhang
    • Somdutta Dhir
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 875-882

  • DNA–protein interactions are essential to genome function, but they are challenging to map in a cellular environment. Now, a chemical proteomics approach, which uses DNA G-quadruplex-specific ligands containing a photocrosslinking motif, has enabled the systematic identification of DNA G-quadruplex-binding proteins in live cells.

    • Xiaoyun Zhang
    • Jochen Spiegel
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    Volume: 13, P: 626-633

  • Single-molecule localization microscopy (SMLM) requires the use of fluorophores with specific sets of properties. Here the authors employ conventional BODIPY dyes as SMLM fluorophores by making use of rarely reported red-shifted ground state BODIPY dimers to image fatty acids, lipid droplets and lysosomes at single-molecule resolution.

    • Santosh Adhikari
    • Joe Moscatelli
    • Elias M. Puchner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • High-temperature polymer electrolyte membrane fuel cells are promising for heavy-duty vehicle applications, but strides in performance are needed to improve their commercial viability. Here it is demonstrated that protonating phosphonic acid electrodes greatly enhances power density and durability.

    • Katie H. Lim
    • Albert S. Lee
    • Yu Seung Kim
    Research
    Nature Energy
    Volume: 7, P: 248-259

  • Whether G-quadruplexes (G4s) regulate stem cell self-renewal and fate determination during embryonic development is not well understood. Here, the authors reveal that the embryonic stem cell state is defined by very high G4 abundance. G4s are progressively lost during differentiation as cells transit to lower lineage potential while artificial G4 stabilisation leads to delayed differentiation.

    • Katherine G. Zyner
    • Angela Simeone
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Quantitative ChIP–seq analysis maps G-quadruplex (G4) DNA structures in breast cancer patient-derived tumor xenograft (PDTX) models. G4-based subtypes highlight additional tumor heterogeneity in the integrative cluster (IC) system.

    • Robert Hänsel-Hertsch
    • Angela Simeone
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 52, P: 878-883