Chemotherapy often leads to premature death of oocytes, and thus infertility, in young individuals with cancer. Here, Stefania Gonfloni and her colleagues show that chemotherapy-induced activation of the kinase c-Abl is responsible for this oocyte failure and that, in vivo, the c-Abl inhibitor imatinib prevents this effect (pages 1124–1125).
- Stefania Gonfloni
- Lucia Di Tella
- Gianni Cesareni