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Showing 1–2 of 2 results
Advanced filters: Author: Sara Cuadrado-Castano Clear advanced filters

  • Genetic disposition can impact response to virus infection. Here, the authors used a reinfection approach with antigenically distinct SARS-CoV-2 variants Omicron and Beta and show that differences in the immune response correlate with disease outcome in mouse models with different genetic background upon reinfection.

    • Gagandeep Singh
    • Juan García-Bernalt Diego
    • Michael Schotsaert
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Strategies to advance T cell based immune therapies are mostly focusing on the improvement of CD8 T cell effector functions, such as cytotoxicity or recruitment to the tumor. Here authors show that by combining in situ vaccination with oncolytic Newcastle Disease Virus and Flt3L-driven dendritic cell expansion, the anti-tumor T cell response is amplified via increased antigen cross-presentation.

    • Judit Svensson-Arvelund
    • Sara Cuadrado-Castano
    • Joshua D. Brody
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18