Nature Search

Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Multiancestry genome-wide association analyses identify new risk loci for stroke and stroke subtypes. Fine mapping and bioinformatics analyses of these risk loci point to mechanisms not previously implicated in stroke pathophysiology.

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Research12 Mar 2018
Nature Genetics

Volume: 50, P: 524-537
Stroke genetics informs drug discovery and risk prediction across ancestries

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Aniket Mishra
Rainer Malik
Stephanie Debette
ResearchOpen Access30 Sept 2022
Nature

Volume: 611, P: 115-123
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing.

Paul K. Potter
Michael R. Bowl
Steve D. M. Brown
ResearchOpen Access18 Aug 2016
Nature Communications

Volume: 7, P: 1-13
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1192-1193
Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO

Daniele Rossini
Sara Lonardi
Chiara Cremolini
ResearchOpen Access07 Oct 2020
British Journal of Cancer

Volume: 124, P: 183-190
CEA increase as a marker of disease progression after first-line induction therapy in metastatic colorectal cancer patients. A pooled analysis of TRIBE and TRIBE2 studies

Roberto Moretto
Daniele Rossini
Chiara Cremolini
Research12 Jul 2021
British Journal of Cancer

Volume: 125, P: 839-845
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.

Nora Franceschini
Claudia Giambartolomei
Christopher J. O’Donnell
ResearchOpen Access03 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Anti-HER agents in gastric cancer: from bench to bedside

Despite some advances, the search for effective treatment modalities for advanced gastric and gastro-esophageal junction cancer (GEJC) is far from over. However, using biologic agents to target key molecular pathways, such as those regulated by human epidermal growth factor receptor (HER) family members, may be an effective approach. This Review briefly describes HER biology, summarizes available data regarding the clinical activity of anti-HER agents and their use in gastric cancer and GEJC, and provides insight into treatment personalization strategies.

Lorenzo Fornaro
Maurizio Lucchesi
Alfredo Falcone
Reviews04 Jul 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 369-383
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra
Rainer Malik
Stephanie Debette
Amendments and CorrectionsOpen Access14 Nov 2022
Nature

Volume: 612, P: E7
Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background

Sara Falcone
Laura Wisby
Paul K. Potter
ResearchOpen Access31 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
Transcriptomic analysis reveals a critical role for activating G_sα mutations in spontaneous feline hyperthyroidism

Thomas K. Hiron
Joana Aguiar
Lucy J. Davison
ResearchOpen Access20 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
The antiplatelet agent revacept prevents the increase of systemic thromboxane A₂ biosynthesis and neointima hyperplasia

Sara Alberti
Qianqian Zhang
Paola Patrignani
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
The tomato genome sequence provides insights into fleshy fruit evolution

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

Shusei Sato
Satoshi Tabata
René M. Klein Lankhorst
ResearchOpen Access30 May 2012
Nature

Volume: 485, P: 635-641
A pharmacogenetic interaction analysis of bevacizumab with paclitaxel in advanced breast cancer patients

Luigi Coltelli
Giacomo Allegrini
Guido Bocci
ResearchOpen Access21 Mar 2022
npj Breast Cancer

Volume: 8, P: 1-9
Clinical significance of enterocyte-specific gene polymorphisms as candidate markers of oxaliplatin-based treatment for metastatic colorectal cancer

Mitsukuni Suenaga
Marta Schirripa
Heinz-Josef Lenz
Research04 Feb 2021
The Pharmacogenomics Journal

Volume: 21, P: 285-295
BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer

Conciatori et al find that BRAF mutations and PTEN-loss promote IL-8 production in colorectal cancer cell (CRC) lines and identify a genetic-context-dependent BRAF/ERK2/CHOP molecular axis that controls IL-8 transcription. These data may assist in the identification of drugs to target CRC.

Fabiana Conciatori
Chiara Bazzichetto
Ludovica Ciuffreda
ResearchOpen Access01 Oct 2020
Communications Biology

Volume: 3, P: 1-13
Differential histopathologic parameters in colorectal cancer liver metastases resected after triplets plus bevacizumab or cetuximab: a pooled analysis of five prospective trials

Chiara Cremolini
Massimo Milione
Filippo Pietrantonio
ResearchOpen Access13 Mar 2018
British Journal of Cancer

Volume: 118, P: 955-965
Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer

Mitsukuni Suenaga
Marta Schirripa
Heinz-Josef Lenz
Research21 Jun 2018
The Pharmacogenomics Journal

Volume: 18, P: 623-632
An explainable model of host genetic interactions linked to COVID-19 severity

A multifaceted computational strategy identifies 16 genetic variants contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing dataset of a cohort of Italian patients.

Anthony Onoja
Nicola Picchiotti
Francesco Raimondi
ResearchOpen Access26 Oct 2022
Communications Biology

Volume: 5, P: 1-14
Ixazomib-based induction regimens plus ixazomib maintenance in transplant-ineligible, newly diagnosed multiple myeloma: the phase II, multi-arm, randomized UNITO-EMN10 trial

Roberto Mina
Antonietta Pia Falcone
Alessandra Larocca
CorrespondenceOpen Access07 Dec 2021
Blood Cancer Journal

Volume: 11, P: 1-5
A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

Francesca Minnai
Filippo Biscarini
Francesca Colombo
ResearchOpen Access06 Feb 2024
Scientific Reports

Volume: 14, P: 1-14
Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer

Fotios Loupakis
Roberto Moretto
Emilio Bria
ResearchOpen Access17 Nov 2015
British Journal of Cancer

Volume: 114, P: 30-36
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

Stefania Mantovani
Sergio Daga
Alessandra Renieri
ResearchOpen Access24 Dec 2021
Genes & Immunity

Volume: 23, P: 51-56

Search

Whole-genome sequencing reveals host factors underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

A second update on mapping the human genetic architecture of COVID-19

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Stroke genetics informs drug discovery and risk prediction across ancestries

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO

CEA increase as a marker of disease progression after first-line induction therapy in metastatic colorectal cancer patients. A pooled analysis of TRIBE and TRIBE2 studies

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Anti-HER agents in gastric cancer: from bench to bedside

A first update on mapping the human genetic architecture of COVID-19

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background

Transcriptomic analysis reveals a critical role for activating G_sα mutations in spontaneous feline hyperthyroidism

The antiplatelet agent revacept prevents the increase of systemic thromboxane A₂ biosynthesis and neointima hyperplasia

The tomato genome sequence provides insights into fleshy fruit evolution

A pharmacogenetic interaction analysis of bevacizumab with paclitaxel in advanced breast cancer patients

Clinical significance of enterocyte-specific gene polymorphisms as candidate markers of oxaliplatin-based treatment for metastatic colorectal cancer

BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer

Differential histopathologic parameters in colorectal cancer liver metastases resected after triplets plus bevacizumab or cetuximab: a pooled analysis of five prospective trials

Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer

An explainable model of host genetic interactions linked to COVID-19 severity

Ixazomib-based induction regimens plus ixazomib maintenance in transplant-ineligible, newly diagnosed multiple myeloma: the phase II, multi-arm, randomized UNITO-EMN10 trial

A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

Search

Quick links

Search

Filter By:

Search

Quick links