Monticelli and colleagues analyze primary human CD4+ T cells to interrogate gene expression regulatory pathways that distinguish GM-CSF+ pathogenic programs from noninflammatory programs. They identify the transcriptional repressor BHLHE40 as an enforcer of proinflammatory gene expression by suppressing the NF-κB inhibitor miR-146a and the RNase ZC3H12D.
- Stefan Emming
- Niccolò Bianchi
- Silvia Monticelli