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Showing 1–2 of 2 results
Advanced filters: Author: Sara Thodberg Clear advanced filters
  • Thodberg et al. report the first step of the synthesis of cyanogenic glycosides, a plant defense mechanism, by a Flavin-dependent monooxygenase (FOS1) in ferns, revealing convergent evolution of biosynthesis across the plant kingdom. The authors isolate FOS1 as a catalytically active dimer and demonstrate that it catalyzes the formation of N-hydroxylated amino acids.

    • Sara Thodberg
    • Mette Sørensen
    • Elizabeth Heather Jakobsen Neilson
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11
  • P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity towards CYP redox partners, activating distinct metabolic cascades in cells.

    • Simon Bo Jensen
    • Sara Thodberg
    • Nikos S. Hatzakis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14