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Showing 1–2 of 2 results
Advanced filters: Author: Sarah C. Mullaly Clear advanced filters

  • Sohrab Shah, Samuel Aparicio and colleagues analyze whole genomes and single cells from ovarian cancers in the peritoneal cavity to establish patterns of disease spread. They determine the clonal relationships between multiple tumor sites and characterize the migratory potential of genomically diverse clones.

    • Andrew McPherson
    • Andrew Roth
    • Sohrab P Shah
    Research
    Nature Genetics
    Volume: 48, P: 758-767

  • Assessing functional impact of mutations in cancer on gene expression can improve our understanding of cancer biology and may identify potential therapeutic targets. Here, Ding et al. describe a novel statistical model named xseq for a systematic survey of how mutations impact transcriptome landscapes across 12 different tumour types.

    • Jiarui Ding
    • Melissa K. McConechy
    • Sohrab P. Shah
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13