Nature Search

USP1-trapping lesions as a source of DNA replication stress and genomic instability

Here the authors provide mechanistic insights into how auto-cleavage of the USP1 deubiquitinase regulates DNA replication and genome stability. Implications for the targeting of USP1 activity via protein-DNA trapping in cancer therapy are discussed.

Kate E. Coleman
Yandong Yin
Tony T. Huang
ResearchOpen Access01 Apr 2022
Nature Communications

Volume: 13, P: 1-19
Multi-ancestry polygenic mechanisms of type 2 diabetes

A multi-ancestry analysis in large cohorts of patients with type 2 diabetes (T2D) identified 12 disease genetic clusters with distinct cardiometabolic trait associations, including two lipodystrophy-related clusters that could provide insights on the increased T2D susceptibility in East Asian ancestries at a given body mass index level.

Kirk Smith
Aaron J. Deutsch
Miriam S. Udler
Research05 Mar 2024
Nature Medicine

Volume: 30, P: 1065-1074
Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

Kenny K. H. Yu
Sreyashi Basu
Nathalie Y. R. Agar
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-23
A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

Sarah E. Polk
Fredrik Öhman
David Berron
ResearchOpen Access10 May 2025
npj Digital Medicine

Volume: 8, P: 1-14
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.

Yanjun Guo
Pamela M. Rist
Daniel I. Chasman
ResearchOpen Access06 Jul 2020
Nature Communications

Volume: 11, P: 1-11
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies

Tarana Parvez Kaovasia
Sarah Duclos
Timothy L. Hall
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Using a co-created transdisciplinary approach to explore the complexity of air pollution in informal settlements

Sarah E. West
Cressida J. Bowyer
Heather D. Price
ResearchOpen Access19 Nov 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-13
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide

Caryn E. Plummer
Timothy Polk
Joseph Larkin III
ResearchOpen Access03 May 2022
Scientific Reports

Volume: 12, P: 1-11
Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma

Stephen J. O’Brien
Casey Fiechter
Susan Galandiuk
ResearchOpen Access26 Mar 2021
Cell Death Discovery

Volume: 7, P: 1-14
Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program

Frances A. Tylavsky
Assiamira Ferrara
Leonardo Trasande
Research24 Oct 2019
International Journal of Obesity

Volume: 44, P: 617-627
The role and function of IκKα/β in monocyte impairment

Norman J. Galbraith
Sarah A. Gardner
Susan Galandiuk
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
Weight Gain in Infancy and Overweight or Obesity in Childhood across the Gestational Spectrum: a Prospective Birth Cohort Study

Guoying Wang
Sara Johnson
Xiaobin Wang
ResearchOpen Access15 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Pneumocystis jirovecii Infection in autologous hematopoietic stem cell transplant recipients

John Coda
Kadee Raser
Matthew J. Pianko
Correspondence22 Dec 2022
Bone Marrow Transplantation

Volume: 58, P: 446-451

Search

USP1-trapping lesions as a source of DNA replication stress and genomic instability

Multi-ancestry polygenic mechanisms of type 2 diabetes

Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Using a co-created transdisciplinary approach to explore the complexity of air pollution in informal settlements

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide

Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma

Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program

The role and function of IκKα/β in monocyte impairment

Weight Gain in Infancy and Overweight or Obesity in Childhood across the Gestational Spectrum: a Prospective Birth Cohort Study

Pneumocystis jirovecii Infection in autologous hematopoietic stem cell transplant recipients

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