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Showing 1–2 of 2 results
Advanced filters: Author: Sarah Rösing Clear advanced filters
  • Myotonic dystrophy type 2 is characterized by large CCUG repeats in the CNBP gene that result in myopathy. Here, the authors show that recognition of aberrant protein translation derived from these repeats leads to ER stress and mitochondrial DNA release, leading to cGAS/STING activation and type-I IFN responses.

    • Sarah Rösing
    • Fabian Ullrich
    • Claudia Günther
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • NLRP10 has been considered as an inflammasome inhibitor. Here the authors show that upon mitochondrial rupture, NLRP10 assembles a canonical inflammasome and is highly expressed in differentiated keratinocytes, possibly supporting skin homeostasis.

    • Tomasz Próchnicki
    • Matilde B. Vasconcelos
    • Eicke Latz
    Research
    Nature Immunology
    Volume: 24, P: 595-603