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Showing 1–2 of 2 results
Advanced filters: Author: Sarah Stöcker Clear advanced filters

  • A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.

    • Mirko C Sobotta
    • Willy Liou
    • Tobias P Dick
    Research
    Nature Chemical Biology
    Volume: 11, P: 64-70

  • Cytosolic 2-Cys peroxiredoxins can enable, rather than compete with, rapid thiol oxidation by relaying H2O2-derived oxidizing equivalents to other proteins, suggesting a broadened role for peroxiredoxins as sensors and transmitters of H2O2 signals.

    • Sarah Stöcker
    • Michael Maurer
    • Tobias P Dick
    Research
    Nature Chemical Biology
    Volume: 14, P: 148-155