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Advanced filters: Author: Sarah Zvornicanin Clear advanced filters

  • The expansion of GGGGCC repeats in the C9ORF72 gene results in the production of disease causing abnormal proteins with polymeric glycine-arginine (poly-GR) and polymeric proline-arginine (poly-PR). Here the authors demonstrate a structural mechanism of how poly-GR and poly-PR inhibit translation and how they might also perturb ribosome assembly.

    • Anna B. Loveland
    • Egor Svidritskiy
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13