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Showing 1–4 of 4 results
Advanced filters: Author: Saran Bao Clear advanced filters

  • At present, there are no countermeasures against the GI genogroup of noroviruses. The authors characterize a protective human antibody that broadly recognizes this genogroup.

    • Inga Rimkute
    • Adam S. Olia
    • Mario Roederer
    Research
    Nature Microbiology
    Volume: 10, P: 1227-1239

  • SARS-CoV-2 evolution poses a risk to vaccine and antiviral drug efficacy. Here, Gagne et al. report the development of a variant-agnostic protein, RBD-62, with enhanced ACE2 binding obtained through in vitro evolution and show that RBD-62 inhalation protects nonhuman primates against SARS-CoV-2 Delta challenge.

    • Matthew Gagne
    • Barbara J. Flynn
    • Daniel C. Douek
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Vaccines that protect nonhuman primates from lethal Ebola virus infection have been developed, but their protective mechanisms have not been clearly delineated. Nancy Sullivan et al. now report that the protective efficacy of a recombinant Ad5-based Ebola virus vaccine relies primarily on CD8+ T cells rather than on antibodies. The findings suggest that clinical development of T cell–based vaccines against Ebola virus is warranted.

    • Nancy J Sullivan
    • Lisa Hensley
    • Gary J Nabel
    Research
    Nature Medicine
    Volume: 17, P: 1128-1131

  • A mutation in VRC01, a broadly neutralizing, HIV-1-specific antibody, confers enhanced binding to the neonatal Fc receptor, increasing the antibody half-life in the serum and localization in mucosal tissues, where it provides superior protection against rectal simian HIV-1 infection in macaques.

    • Sung-Youl Ko
    • Amarendra Pegu
    • Gary J. Nabel
    Research
    Nature
    Volume: 514, P: 642-645