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Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

Mutation of positively charged binding sites on the eastern equine encephalitis virus (EEEV) E2 glycoprotein affects both heparan sulfate and protein receptor binding, identifying an unexpected linkage between engagement of these two receptor types.

Maria D. H. Alcorn
Chengqun Sun
William B. Klimstra
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Sensitive detection of dengue serotype-4 on lignin-derived graphene nanofibre and manganese oxide composite by DNA-sensing

Sivainesh Devi Remesh
Saravanan Karuppanan
Raju Suresh Kumar
ResearchOpen Access15 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Author Correction: Mucosal vaccine-induced cross-reactive CD8⁺ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

Baoling Ying
Tamarand L. Darling
Michael S. Diamond
Amendments and CorrectionsOpen Access15 Feb 2024
Nature Immunology

Volume: 25, P: 578
The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses

Ma et al. identify LDLR as an entry receptor for Eastern equine encephalitis virus (EEEV) and other alphaviruses. Soluble decoy proteins with multiple LA domain 3 repeats of LDLR inhibit EEEV infection in cell culture and mice.

Hongming Ma
Lucas J. Adams
Michael S. Diamond
ResearchOpen Access04 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines

In mouse experiments and in clinical trials in humans, boosting with Omicron-specific mRNA following immunization with Wuhan-1 spike mRNA results in immune responses focused on conserved rather than variant-specific epitopes.

Chieh-Yu Liang
Saravanan Raju
Michael S. Diamond
Research15 May 2024
Nature

Volume: 630, P: 950-960
Mucosal vaccine-induced cross-reactive CD8⁺ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

Here, the authors enhance their nasally delivered chimpanzee adenoviral-vectored SARS-CoV-2 vaccine with an Omicron-matched vaccine (ChAd-SARS-CoV-2-BA.5-S) that stimulates mucosal immunity in mice and hamsters and shows cross-reactive CD8⁺ memory T cell-driven protection against antigenically distant strains.

Baoling Ying
Tamarand L. Darling
Michael S. Diamond
ResearchOpen Access09 Feb 2024
Nature Immunology

Volume: 25, P: 537-551
AHP VIKOR framework for selecting wind turbine materials with a focus on corrosion and efficiency

Sekar Kidambi Raju
Saravanan Natesan
El-Sayed M. El-kenawy
ResearchOpen Access14 Oct 2024
Scientific Reports

Volume: 14, P: 1-22
Emergence of SARS-CoV-2 omicron variant JN.1 in Tamil Nadu, India - Clinical characteristics and novel mutations

Sivaprakasam T. Selvavinayagam
Sathish Sankar
Sivadoss Raju
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-15

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