Bruton's tyrosine kinase (BTK) is important in B cell receptor (BCR) signalling, and so BTK is altered in many types of B cell-derived malignancy. This Review discusses the molecular biology of BTK, its involvement in the pathogenesis of B cell malignancies and the current efforts to therapeutically target it.
- Rudi W. Hendriks
- Saravanan Yuvaraj
- Laurens P. Kil