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Showing 1–3 of 3 results
Advanced filters: Author: Sarita Namjoshi Clear advanced filters

  • GRB2 is known for its role in Receptor Tyrosine Kinase and RAS signaling. Here the authors unveil a GRB2 function and mechanism for DNA replication fork protection. GRB2 alleviates oncogenic replication stress, and in doing so, averts cancer immune destruction by inhibiting cGAS/STING and pro-inflammatory cytokine production.

    • Zu Ye
    • Shengfeng Xu
    • Zamal Ahmed
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Dynamin promotes membrane fission by constricting the neck of invaginating membranes; however, it was recently shown that dynamin also regulates membrane fusion. Here the authors show that this fusogenic activity is mediated by interaction with the Qa SNARE, thereby promoting trans-SNARE formation.

    • Kannan Alpadi
    • Aditya Kulkarni
    • Christopher Peters
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.

    • Jerry H. Houl
    • Zu Ye
    • John A. Tainer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15