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Showing 1–4 of 4 results
Advanced filters: Author: Sascha Gutmann Clear advanced filters
  • Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.

    • Melusine Bleu
    • Fanny Mermet-Meillon
    • Giorgio Giacomo Galli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • Certain bacterial enzymes are packaged within protein chambers that provide a confined environment for their reactions to take place. Ban and colleagues now identify a family of proteins that form nanocompartments, similar to bacterial microcompartments such as the carboxysome, and show that the enzymes within are anchored by their C-terminal extensions to binding sites on the inner surface of the chamber.

    • Markus Sutter
    • Daniel Boehringer
    • Nenad Ban
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 939-947