Immunoglobulin E–mediated crosslinking of FɛRI receptors can lead to life-threatening anaphylaxis in sensitized people. Shibuya and colleagues identify a phosphatase-recruiting inhibitory receptor, Allergin-1, that suppresses mast cell degranulation induced by immunoglobulin E–FɛRI.
- Kaori Hitomi
- Satoko Tahara-Hanaoka
- Akira Shibuya