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Showing 1–4 of 4 results

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Erratum: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa
Yuuki Obata
Hiroshi Ohno
Amendments and Corrections12 Feb 2014
Nature

Volume: 506, P: 254
Gut microorganisms act together to exacerbate inflammation in spinal cords

Germ-free mice co-colonized with two bacterial strains from the small intestinal flora showed increased susceptibility to experimental autoimmune encephalomyelitis, implicating the synergistic effects of these microorganisms in this mouse model of multiple sclerosis.

Eiji Miyauchi
Seok-Won Kim
Hiroshi Ohno
Research26 Aug 2020
Nature

Volume: 585, P: 102-106
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Regulatory T cells proliferate robustly in gut lymphoid tissues. Hase et al. show that this proliferation requires their expression of the epigenetic regulator Uhrf1, which is increased in response to IL-2 produced by effector T cells.

Yuuki Obata
Yukihiro Furusawa
Koji Hase
Research28 Apr 2014
Nature Immunology

Volume: 15, P: 571-579
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

The gut microbial metabolite butyrate is shown to induce the differentiation of colonic T regulatory cells in mice and to ameliorate the development of colitis; it also increases histone H3 acetylation at the Foxp3 promoter.

Yukihiro Furusawa
Yuuki Obata
Hiroshi Ohno
Research13 Nov 2013
Nature

Volume: 504, P: 446-450