A facile method of preparing cyclodextrin-grafted chitosan (CyD-g-CS) by means of the carboxymethlation of cyclodextrins and the dehydration-condensation reaction to chitosan was developed. In this method, crude product containing ~10% of the carboxymethylated-cyclodextrin was subjected to the grafting reaction without further purification. The product (CyD-g-CS) was finally purified by dialysis. Furthermore, doxorubicin-capturing nanoparticles composed of CyD-g-CS and sodium triphosphate were prepared.
- Hironori Izawa
- Keisuke Yamamoto
- Hiroyuki Saimoto
