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Showing 1–2 of 2 results
Advanced filters: Author: Satyapramod Murthy Clear advanced filters

  • Hepatitis C virus lacks an effective vaccine, partly due to the absence of suitable animal models for testing. Here, the authors develop a live-attenuated vaccine, using synonymous mutagenesis in rodent hepacivirus, and demonstrate induction of a protective T cell response and protection from chronic infection in rats.

    • Sheetal Trivedi
    • Piyush Dravid
    • Amit Kapoor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.

    • Alex S. Hartlage
    • Satyapramod Murthy
    • Amit Kapoor
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11