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Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
Amendments and CorrectionsOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

Lei Xiong
Feng Wu
Ka-Fai To
ResearchOpen Access18 Jan 2019
Nature Communications

Volume: 10, P: 1-14
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.

Yvonne Y Li
Grace T. Y. Chung
Kwok-Wai Lo
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-10
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

The lack of appropriate models restricts pre-clinical research for nasopharyngeal carcinoma (NPC). Here the authors report the development and characterization of NPC patient-derived xenografts (PDXs), and EBV positive NPC cell line from patient tumor, and suggest their potential use in future NPC research.

Weitao Lin
Yim Ling Yip
Sai Wah Tsao
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-17

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Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

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