In this work, we report a novel Dean vortices-induced particle migration phenomenon in spiral inertial microfluidics, which can be utilized for high throughput size-based separation of sub-micrometer synthetic or biological components, aptly termed as high-resolution Dean flow fractionation (HiDFF). We demonstrated enhanced drug release effects in particle-based drug delivery system, as well as single-step purification of circulating extracellular microvesicles from whole blood for rapid immune and vascular health profiling.
- Hui Min Tay
- Sharad Kharel
- Han Wei Hou
