Nature Search

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Stress- and ubiquitylation-dependent phase separation of the proteasome

Hyperosmotic stress leads to a phase separation of the proteasome, triggered by interactions between RAD23B and ubiquitylated proteins, which bring together p97 and proteasome-associated proteins into nuclear proteolytic foci.

Sayaka Yasuda
Hikaru Tsuchiya
Yasushi Saeki
Research05 Feb 2020
Nature

Volume: 578, P: 296-300
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

Stem cells have raised hopes of developing regenerative therapies of renal disease. Here, Osafune et al.provide a protocol for the differentiation of induced human pluripotent stem cells into renal lineages with the capacity to form tubular renal structures in mice.

Shin-Ichi Mae
Akemi Shono
Kenji Osafune
Research22 Jan 2013
Nature Communications

Volume: 4, P: 1-11
Usability assessment of drug-linking laboratory data listed on prescriptions for outpatients of chiba university hospital

Iichiro Yokoyama
Hiroki Yamaguchi
Itsuko Ishii
ResearchOpen Access18 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products

Sayaka Masada
Genichiro Tsuji
Haruhiro Okuda
ResearchOpen Access14 Aug 2019
Scientific Reports

Volume: 9, P: 1-6
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

The mislocalization and downregulation of the proteins TDP-43 and ADAR2, respectively, are implicated in amyotrophic lateral sclerosis pathology. Yamashita et al. find that downregulation of ADAR2 results in calcium-permeable AMPA receptor-mediated calpain activation and subsequent aberrant cleavage of TDP-43.

Takenari Yamashita
Takuto Hideyama
Shin Kwak
Research18 Dec 2012
Nature Communications

Volume: 3, P: 1-13
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Comprehensive assessment of left atrial and ventricular remodeling in paroxysmal atrial fibrillation by the cardiovascular magnetic resonance myocardial extracellular volume fraction and feature tracking strain

Akimasa Yamada
Naoki Hashimoto
Yasuo Okumura
ResearchOpen Access25 May 2021
Scientific Reports

Volume: 11, P: 1-12
DPP8 is a novel therapeutic target for multiple myeloma

Tsutomu Sato
Ayumi Tatekoshi
Chikao Morimoto
ResearchOpen Access02 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

Yuki Yoshizaki
Takayasu Mori
Eisei Sohara
ResearchOpen Access21 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Shintaro Mandai
Susumu Furukawa
Shinichi Uchida
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

Tomonaga Ameku
Daisuke Taura
Kenji Osafune
ResearchOpen Access15 Jul 2016
Scientific Reports

Volume: 6, P: 1-14
Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

Kennosuke Tsuda
Takeo Mukai
Kayo Yoshikawa
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
G0S2 regulates innate immunity in Kawasaki disease via lncRNA HSD11B1-AS1

Mako Okabe
Shinya Takarada
Keiichi Hirono
Research15 Mar 2022
Pediatric Research

Volume: 92, P: 378-387

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