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Showing 1–6 of 6 results
Advanced filters: Author: Scott A. Lacadie Clear advanced filters

  • METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors identify a noncoding regulatory region at the Fgf9 locus and reveal that Meis genes are key regulators of sexual differentiation.

    • Irene Mota-Gómez
    • Juan Antonio Rodríguez
    • Darío G. Lupiáñez
    ResearchOpen Access
    Nature Structural & Molecular Biology
    P: 1-13

  • Divergent transcription from promoters and enhancers occurs in many species, but it is unclear if it is a general feature of all eukaryotic cis regulatory elements. Here the authors define cis regulatory elements in worms, flies, and human; and identify several differences in regulatory architecture among metazoans.

    • Mahmoud M. Ibrahim
    • Aslihan Karabacak
    • Uwe Ohler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Xu and colleagues show that the transcription factor Hand2 promotes pdgfra expression during early cardiogenesis and that it can do so independently of direct DNA binding by interacting with Tcf3.

    • Yanli Xu
    • Rupal Gehlot
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 3, P: 1531-1548

  • Control of gene activity through transcriptional regulatory elements is a major driving force in human evolution. A new study measures nascent transcription directly and shows that sequence, activity and three-dimensional organization of transcriptional regulatory elements all contribute to the evolution of gene activity within primate CD4+ T cells.

    • Scott A. Lacadie
    • Uwe Ohler
    News & Views
    Nature Ecology & Evolution
    Volume: 2, P: 418-419

  • In a zebrafish model of melanoma driven by activated BRAF, this study finds expression of a gene signature indicative of disrupted terminal differentiation of neural crest progenitors. A chemical screen led to the identification of leflunomide as an inhibitor of neural crest stem cells. Leflunomide inhibits dihydroorotate dehydrogenase and thereby transcriptional elongation, including genes involved in neural crest development and melanoma growth. Leflunomide has anti-melanoma activity in the zebrafish model and human melanoma xenografts, and might prove useful as an anticancer drug.

    • Richard Mark White
    • Jennifer Cech
    • Leonard I. Zon
    Research
    Nature
    Volume: 471, P: 518-522