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Showing 1–2 of 2 results
Advanced filters: Author: Scott Bowdridge Clear advanced filters

  • The regulation of gene expression through changes in chromatin structure is increasingly recognized as a chief component of activation of cells of the immune response. It now seems that histone demethylation of the promoter of the gene encoding the transcription factor IRF4 contributes to alternative macrophage activation.

    • Scott Bowdridge
    • William C Gause
    News & Views
    Nature Immunology
    Volume: 11, P: 879-881

  • Protective T helper 2 (TH2)-type responses are induced by parasite infection and can control inflammation and induce parasite expulsion. In this issue, Chen et al. report that in a mouse model of helminth infection, TH2-type responses protect against acute lung tissue damage by both suppressing inflammation and promoting macrophage-associated wound healing.

    • Fei Chen
    • Zhugong Liu
    • William C Gause
    Research
    Nature Medicine
    Volume: 18, P: 260-266