Nature Search

Optical hyperpolarization and NMR detection of ¹²⁹Xe on a microfluidic chip

Hyperpolarized ¹²⁹Xe gas is used as a contrast agent in nuclear magnetic resonance imaging. Here, the authors demonstrate a microfluidic chip that optically polarizes ¹²⁹Xe gas for compact nuclear magnetic resonance imaging applications.

Ricardo Jiménez-Martínez
Daniel J. Kennedy
John Kitching
Research20 May 2014
Nature Communications

Volume: 5, P: 1-6
A generic non-invasive neuromotor interface for human-computer interaction

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Patrick Kaifosh
Thomas R. Reardon
Danny Zlobinsky
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 702-711
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Tingxiang Yan
Jingjing Liang
Xinglong Wang
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Optically detected cross-relaxation spectroscopy of electron spins in diamond

In nanoscale magnetic resonance, the coupling with negatively charged nitrogen-vacancy centres in diamond—used as optical transducers—broadens the spectrum of the spin to detect. Wang et al.present a detection technique that resolves the spin spectra through optically detected cross-relaxation.

Hai-Jing Wang
Chang S. Shin
Vikram S. Bajaj
Research18 Jun 2014
Nature Communications

Volume: 5, P: 1-8
Sensitive magnetic control of ensemble nuclear spin hyperpolarization in diamond

The transfer of spin polarization from electrons to nuclei is important for nuclear spin-based techniques such as nuclear magnetic resonance. Here Wang and colleagues achieve sensitive magnetic control of the hyperpolarization of nuclei near optically polarized nitrogen-vacancy centres in diamond.

Hai-Jing Wang
Chang S. Shin
Vikram S. Bajaj
Research05 Jun 2013
Nature Communications

Volume: 4, P: 1-7
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease

Neuroinflammation is observed in Alzheimer’s disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker.

William T. Hu
Tugba Ozturk
Gloria Chiang
ResearchOpen Access28 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
An empirical estimate of carrier frequencies for 400+ causal Mendelian variants: results from an ethnically diverse clinical sample of 23,453 individuals

Gabriel A. Lazarin
Imran S. Haque
Balaji S. Srinivasan
ResearchOpen Access13 Sept 2012
Genetics in Medicine

Volume: 15, P: 178-186
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe

Daniel J. Kennedy
Scott J. Seltzer
Alexander Pines
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub
Mohamed Ali Mahjoub
Kristin Fargher
ResearchOpen Access07 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Asha Singanamalli
Haibo Wang
Kristin Fargher
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

Haochen Liu
Xiaoting Zhou
Kristin Fargher
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Donghuan Lu
Karteek Popuri
Kristin Fargher
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Meiyan Huang
Wei Yang
Kristin Fargher
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Lin Tan
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-12
Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease

Xiaoke Hao
Chanxiu Li
Kristin Fargher
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Benjamin Goudey
Bowen J. Fung
Brenda Plassman
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Emrin Horgusluoglu-Moloch
Shannon L. Risacher
Kristin Fargher
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Wei Xu
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Author Correction: Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
Amendments and CorrectionsOpen Access01 Aug 2023
Scientific Reports

Volume: 13, P: 1
Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
Amendments and CorrectionsOpen Access30 Jun 2020
Scientific Reports

Volume: 10, P: 1

Search

Optical hyperpolarization and NMR detection of ¹²⁹Xe on a microfluidic chip

A generic non-invasive neuromotor interface for human-computer interaction

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Optically detected cross-relaxation spectroscopy of electron spins in diamond

Sensitive magnetic control of ensemble nuclear spin hyperpolarization in diamond

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease

Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

An empirical estimate of carrier frequencies for 400+ causal Mendelian variants: results from an ethnically diverse clinical sample of 23,453 individuals

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe

A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease

A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Author Correction: Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification

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