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Showing 1–2 of 2 results
Advanced filters: Author: Scott Smemo Clear advanced filters

  • Internal modifications in mRNA and non-coding RNA are necessary for modulating various intracellular signalling pathways. In this study, the authors report novel modifications resulting from oxidative RNA demethylation, which regulate RNA–protein interactions affecting gene expression.

    • Ye Fu
    • Guifang Jia
    • Chuan He
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Obesity-associated noncoding sequences within FTO are functionally connected with IRX3, and long-range enhancers in this region recapitulate aspects of IRX3 expression, suggesting that the obesity-associated interval is part of IRX3 regulation; Irx3-deficient mice have lower body weight and are resistant to diet-induced obesity, suggesting IRX3 as a novel determinant of body mass and composition.

    • Scott Smemo
    • Juan J. Tena
    • Marcelo A. Nóbrega
    Research
    Nature
    Volume: 507, P: 371-375