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Showing 1–9 of 9 results
Advanced filters: Author: Seán E. O’Leary Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.

    • Wendan Ren
    • Huitao Fan
    • Jikui Song
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.

    • Boxiao Wang
    • Stephanie Thurmond
    • Jikui Song
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 875-885

  • The early steps of ribosome assembly occur co-transcriptionally on the nascent ribosomal RNA. Here the authors demonstrate an approach that allows simultaneous monitoring of transcription and ribosomal protein assembly at the single-molecule level in real time.

    • Olivier Duss
    • Galina A. Stepanyuk
    • James R. Williamson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • During translation, elongation factor G (EF-G) and transfer RNAs alternately bind the ribosome to direct protein synthesis. Using single-molecule fluorescence with zero-mode waveguide, EF-G–GTP is shown to continuously sample both rotational states of the ribosome, binding with higher affinity to the rotated state to stimulate translocation and return to the nonrotated state.

    • Jin Chen
    • Alexey Petrov
    • Joseph D Puglisi
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 718-727

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • To investigate the mechanism of frameshifting during messenger RNA translation, a technique was developed to monitor translation of single molecules in real time using Förster resonance energy transfer (FRET); ribosomes were revealed to pause tenfold longer than usual during elongation at the frameshifting sites.

    • Jin Chen
    • Alexey Petrov
    • Joseph D. Puglisi
    Research
    Nature
    Volume: 512, P: 328-332