The engulfment receptor Draper is known to promote glial clearance of degenerating neurons in Drosophila, and this action of Draper is mediated by Src kinase. This study now shows that one of three Draper isoforms, namely Draper-II, negatively regulates glial clearance and acts in opposition to pro-clearance Draper-I.
- Mary A Logan
- Rachel Hackett
- Marc R Freeman