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Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx cohort reveal the role of transcriptional events in tumour evolution.

A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

Meyer and colleagues use fluorescent biosensors to demonstrate that chemotactic steering and cell polarization are controlled by locally excitable Cdc42 signalling.

Mucosal surfaces are a primary route of HIV entry, yet the compartmentalisation between mucosal and peripheral immune systems remain a challenge for HIV vaccine candidates. Authors utilise a combination of intranodal tonsil MALT and systemic vaccination in the rhesus macaque model to explore immune responses and protection from highly pathogenic simian homologue of HIV.

A low-dose, single-exposure electron diffraction approach is used to reveal the dislocation character and operative slip systems in beam-sensitive molecular crystals.

Small semiconductor nanocrystals control the assembly of larger plasmonic nanostructures through interfacial self-limiting aggregation, leading to permeable and colloidally stable photoactive hybrids for photocatalysis and tracking of light-induced electron transfer.

The structures of amorphous MOFs are challenging to characterise. Here the authors use electron microscopy and pair distribution function methods, coupled with a polymerisation-based algorithm to determine the atomic structure of Fe-BTC, demonstrating the power of this computational approach.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.

Profiling the immune responses of 56 volunteers vaccinated with BNT162b2 reveals how this mRNA vaccine primes the innate immune system to mount a potent response to SARS-CoV-2 after booster immunization.

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists’ forecasts were on average no more accurate than those of simple statistical models.

Interactions between subducting slabs and the 660-km mantle transition zone can influence mantle convection and forearc uplift, according to rock uplift histories of the Calabrian forearc spanning the past 30 million years.

Froudist-Walsh et al. reveal organizational principles of receptor densities in macaque cortex. Densities of multiple receptor types align with changes in dendritic properties, myelin and functional networks. Data are openly released to the community.

Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.

Induction of protective immunity mediated by CD8⁺ T cells has been a long sought goal in vaccinology. Here, Ewer et al. report induction of protective efficacy against Plasmodium falciparummalaria in a phase IIa prime-boost vaccine trial where efficacy correlates strongly with induced CD8 T-cell responses.

The biogenesis and stereochemical origin of many natural products remain unknown. Now the biosynthetic pathway of brevianamide A is elucidated. An isomerase is discovered that can catalyse pinacol rearrangement without a cofactor and determine the stereochemistry of the bicyclo[2.2.2]diazaoctane ring.

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.

An epistatic miniarray profile allows identification of multiprotein complexes involved in various aspects of chromosome biology. In one pathway, the histone acetyltransferase Rtt109 is found to modify histone H3 lysine 56 during DNA replication.

A longitudinal evolutionary analysis of 126 lung cancer patients with metastatic disease reveals the timing of metastatic divergence, modes of dissemination and the genomic events subject to selection during the metastatic transition.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

The segmentation motor activity of the small intestine is believed to be a result of alternating inhibitory and excitatory neural activity. Huizinga et al.show that the segmentation motor pattern is in fact a result of phase–amplitude interactions of slow-wave activities generated by two networks of interstitial cells of Cajal.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

Leaves vary their temperatures to improve their physiological performance. Theoretical considerations predict, and data for diverse taxa show, a moderate level of leaf thermoregulation maximizing net carbon assimilation.

To increase the range and precision of genetic interaction studies in Saccharomyces cerevisiae, a collection of hypomorphic alleles of essential yeast genes and a highly sensitive flow cytometry–based growth competition assay are presented. Also in this issue, Yan et al. present a similar strain collection, tagged with unique bar-code identifiers, and use this collection in pooled chemical genetic screens.

It is hoped that quantum computers may be faster than classical ones at solving optimization problems. Here the authors implement a quantum optimization algorithm over 23 qubits but find more limited performance when an optimization problem structure does not match the underlying hardware.

An array-based high-throughput approach, genetic interaction analysis technology for Escherichia coli (GIANT-coli), now allows comprehensive genetic interaction screens in bacteria. The method uses bacterial conjugation and robotic technology to generate double mutants on a genome-wide scale. In this issue another paper presents eSGA, a very similar approach.

The formation of composite materials has been widely exploited to alter the chemical and physical properties of their components. Here the authors form metal–organic framework (MOF) crystal–glass composites in which a MOF glass matrix stabilises the open pore structure of MIL-53, leading to enhanced CO₂ adsorption.

Characterization of a family of Stigonematales (Stig) cyclases that catalyze stereoselective intramolecular C–C bond formation reveals the enzymatic origins of the complex stereochemical patterns in hapalindole and fischerindole alkaloids.

The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress recovery.

The aboveground carbon stock of a montane African forest network is comparable to that of a lowland African forest network and two-thirds higher than default values for these montane forests.

The recently introduced glass and liquid states of metal–organic frameworks (MOFs) provide opportunities to design and explore new properties for this class of material. Here, the authors show that a MOF liquid can be blended with another MOF component to produce domain-structured MOF glasses with single, tailorable glass transitions.

Carbon fluxes in the central Himalaya did not change after the 2015 Gorkha earthquake and its accompanying landslides, according to observations of riverine sediment and carbon fluxes over four monsoon seasons spanning the event.

The surge in metal–organic frameworks for diverse applications has stimulated significant interest in their sustainable and scalable production. Here, the authors develop an ultrasound-assisted two-phase flow reaction platform for the continuous aqueous synthesis of MOFs with sulfonate, imidazolate, and carboxylate ligand chemistries, achieving enhanced nucleation and process efficiency.

Cataloging microbial genomes from Earth’s environments expands the known phylogenetic diversity of bacteria and archaea.

The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.