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Showing 1–7 of 7 results
Advanced filters: Author: Sean-Paul Nuccio Clear advanced filters

  • The systemic discovery of metal–small-molecule complexes from biological samples is a difficult challenge. Now, a method based on liquid chromatography and native electrospray ionization mass spectrometry has been developed. The approach uses post-column pH adjustment and metal infusion combined with ion identity molecular networking, and a rule-based informatics workflow, to interrogate small-molecule–metal binding.

    • Allegra T. Aron
    • Daniel Petras
    • Pieter C. Dorrestein
    Research
    Nature Chemistry
    Volume: 14, P: 100-109

  • Zinc is an essential cofactor for bacterial metabolism. Here, the authors show that the probiotic bacterium Escherichia coli Nissle 1917 utilizes the siderophore yersiniabactin as a zincophore, allowing the microbe to grow in zinc-limited media and to thrive in the inflamed gut.

    • Judith Behnsen
    • Hui Zhi
    • Manuela Raffatellu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Enteric bacterial infections are a major cause of morbidity and mortality. In this Review, the authors describe the different types of mucosal defences — including innate and adaptive immune cells, epithelial cells and commensal microorganisms — that protect us against bacterial pathogens in the intestines.

    • Araceli Perez-Lopez
    • Judith Behnsen
    • Manuela Raffatellu
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 135-148

  • Here, Raffatellu and co-workers discuss our growing understanding of how primary bile acids (which are cholesterol-derived molecules synthesized in the liver) and secondary bile acids (which are primary bile acids that have been microbially modified) shape immune responses in health and disease, with a particular focus on bile acids and intestinal immunity.

    • Michael H. Lee
    • Sean-Paul Nuccio
    • Manuela Raffatellu
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 798-809

  • Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.

    • Franziska Faber
    • Lisa Tran
    • Andreas J. Bäumler
    Research
    Nature
    Volume: 534, P: 697-699

  • Certain commensal enterobacteria secrete small proteins called microcins that suppress the growth of other bacteria in the inflamed gut, conferring an intra- and interspecies competitive advantage.

    • Martina Sassone-Corsi
    • Sean-Paul Nuccio
    • Manuela Raffatellu
    Research
    Nature
    Volume: 540, P: 280-283