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Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

Functional diversity of tissue-resident macrophages and signals governing their ontogeny and turnover remain unknown for the majority of tissues. Here the authors describe two phenotypically and functionally distinct long-lived populations of lung interstitial macrophages and their putative blood-derived monocytic precursor.

Joey Schyns
Qiang Bai
Thomas Marichal
ResearchOpen Access03 Sept 2019
Nature Communications

Volume: 10, P: 1-16
Dedicated macrophages organize and maintain the enteric nervous system

Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive function, indicating that the ENS is governed by a dedicated population of resident macrophages that adapt to the timely needs of the ENS.

Maria Francesca Viola
Marta Chavero-Pieres
Guy Boeckxstaens
Research14 Jun 2023
Nature

Volume: 618, P: 818-826
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

Microglia mediate aberrant synapse engulfment in Alzheimer’s disease (AD), but the underlying mechanisms are poorly understood. Here the authors show a perivascular cells-to-microglia crosstalk that induces microglia phagocytic state resulting in synapse engulfment in two mouse models of AD.

Sebastiaan De Schepper
Judy Z. Ge
Soyon Hong
ResearchOpen Access06 Feb 2023
Nature Neuroscience

Volume: 26, P: 406-415
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.

Hannah Van Hove
Liesbet Martens
Kiavash Movahedi
Research06 May 2019
Nature Neuroscience

Volume: 22, P: 1021-1035

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Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

Dedicated macrophages organize and maintain the enteric nervous system

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

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