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Showing 1–4 of 4 results
Advanced filters: Author: Sebastian M. Waszak Clear advanced filters

  • Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration mapping (CESAM), which they use to identify somatic copy-number alterations affecting cis-regulatory elements in cancer. They find that enhancer hijacking leads to overexpression of IRS4 and IGF2 in cancer.

    • Joachim Weischenfeldt
    • Taronish Dubash
    • Jan O Korbel
    Research
    Nature Genetics
    Volume: 49, P: 65-74

  • Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

    • Paul A. Northcott
    • Ivo Buchhalter
    • Peter Lichter
    ResearchOpen Access
    Nature
    Volume: 547, P: 311-317

  • Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups; here active gene regulatory elements in 28 primary medulloblastoma tissues are mapped to reveal differentially regulated enhancers across the different subgroups, allowing insights into the transcription factors that characterize subgroup divergence and the cellular origin of the poorly characterized Group 3 and 4 subgroups.

    • Charles Y. Lin
    • Serap Erkek
    • Paul A. Northcott
    Research
    Nature
    Volume: 530, P: 57-62