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Communications Biology (4)

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Showing 1–4 of 4 results

Advanced filters: Author: Sebastian Fritzwanker Clear advanced filters

HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants

Fritzwanker et al. develop a knock-in transgenic mouse line in which the hemagglutinin epitope tag sequence is fused with the amino-terminus of the µ-opioid receptor. Their model enables more efficient immunodetection of G protein-coupled receptors.

Sebastian Fritzwanker
Lionel Moulédous
Andrea Kliewer
ResearchOpen Access14 Sept 2021
Communications Biology

Volume: 4, P: 1-10
Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited

CRISPR/Cas9 knock-out of GRKs combined with mutagenesis and phospho-specific antibodies reveal the sites of the mu-opioid receptor that underlie the differences in regulation of this receptor by morphine and fentanyl.

Owen Underwood
Sebastian Fritzwanker
Meritxell Canals
ResearchOpen Access02 Aug 2024
Communications Biology

Volume: 7, P: 1-11
In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies

Phosphorylation of receptors is shown to be unstable during routine immunohistochemical procedures in mice thus phosphatase inhibitors should be used alongside phosphosite-specific GPCR antibodies.

Sebastian Fritzwanker
Falko Nagel
Stefan Schulz
ResearchOpen Access15 Apr 2023
Communications Biology

Volume: 6, P: 1-9
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

A G protein-coupled receptors (GPCRs) phosphorylation assay for cell culture plates can be used for ligand profiling and inhibitor screening, as evidenced by the identification of two GRK inhibitor compounds.

Johanna Kaufmann
Nina Kathleen Blum
Stefan Schulz
ResearchOpen Access09 Nov 2022
Communications Biology

Volume: 5, P: 1-11