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Childhood leukaemia in Down’s syndrome primed by blood-cell bias

An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.

Sébastien Malinge
News & Views25 Sept 2024
Nature

Volume: 634, P: 40-42
Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Bispecific antibodies allow for novel therapeutic approaches but industrial-scale production and immunogenicity represent significant challenges. Here Fischer et al.describe a unique human bispecific antibody format that exploits differing light chains to overcome these obstacles.

Nicolas Fischer
Greg Elson
Marie Kosco-Vilbois
ResearchOpen Access12 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

Anouchka P. Laurent
Rishi S. Kotecha
Sébastien Malinge
ReviewsOpen Access20 May 2020
Leukemia

Volume: 34, P: 1984-1999
The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

Elena Ansó
Samuel E. Weinberg
Navdeep S. Chandel
Research15 May 2017
Nature Cell Biology

Volume: 19, P: 614-625
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

An inhibitor of Aurora kinase promotes megakaryocytic differentiation of cells from patients with primary myelofibrosis and shows antifibrotic effects in mouse models of this disease.

Qiang Jeremy Wen
Qiong Yang
John D Crispino
Research16 Nov 2015
Nature Medicine

Volume: 21, P: 1473-1480
The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

Denise Anderson
Patrycja Skut
Laurence C. Cheung
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

David Weinstock and colleagues identify a triplication at chromosome 21q22 that is associated with development of B cell acute lymphoblastic leukemia (B-ALL) that causes B cell self renewal in vitro. They further demonstrate that this triplication leads to overexpression of the nucleosome remodeling protein HMGN1 and loss of H3K27me3, implicating these changes in B-ALL.

Andrew A Lane
Bjoern Chapuy
David M Weinstock
Research20 Apr 2014
Nature Genetics

Volume: 46, P: 618-623
Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia

Rishi S. Kotecha
Sarah M. Trinder
Laurence C. Cheung
CorrespondenceOpen Access27 Feb 2025
Blood Cancer Journal

Volume: 15, P: 1-5
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

A collection of 131 multi-panel pediatric tumor PDX models are generated and characterized in a comprehensive effort to provide support for basic and translational research and treatment development in advanced pediatric malignancies.

Maria Eugénia Marques Da Costa
Sakina Zaidi
Birgit Geoerger
ResearchOpen Access18 Sept 2023
Communications Biology

Volume: 6, P: 1-15
Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy

Laurence C. Cheung
Carlos Aya-Bonilla
Rishi S. Kotecha
ResearchOpen Access15 Nov 2022
Leukemia

Volume: 37, P: 61-71
Passive limitation of surface contamination by perFluoroDecylTrichloroSilane coatings in the ISS during the MATISS experiments

Laurence Lemelle
Sébastien Rouquette
Christophe Place
ResearchOpen Access04 Aug 2022
npj Microgravity

Volume: 8, P: 1-8
Towards a passive limitation of particle surface contamination in the Columbus module (ISS) during the MATISS experiment of the Proxima Mission

Laurence Lemelle
Lucie Campagnolo
Christophe Place
ResearchOpen Access20 Oct 2020
npj Microgravity

Volume: 6, P: 1-7

Search

Childhood leukaemia in Down’s syndrome primed by blood-cell bias

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy

Passive limitation of surface contamination by perFluoroDecylTrichloroSilane coatings in the ISS during the MATISS experiments

Towards a passive limitation of particle surface contamination in the Columbus module (ISS) during the MATISS experiment of the Proxima Mission

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