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Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

STDP is dependent on the timing of pre- and post-synaptic activity. Here, the authors describe a symmetric STDP induction rule at CA3-CA3 synapses, which induces LTP over a broad range of paring intervals. Modelling suggests that this STDP rule may enhance storage capacity and pattern completion in the CA3 cell network.

Rajiv K. Mishra
Sooyun Kim
Peter Jonas
ResearchOpen Access13 May 2016
Nature Communications

Volume: 7, P: 1-11
A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids

Cortical development is influenced by morphogen gradients. To mimic patterning events during brain development, polarized cortical assembloids are generated with the help of a localized FGF8 source.

Camilla Bosone
Davide Castaldi
Jürgen Arthur Knoblich
ResearchOpen Access18 Sept 2024
Nature Methods

Volume: 21, P: 2147-2159
Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons

This study describes the properties of dendritic electrogenesis in rat hippocampal CA3 pyramidal neurons and distinguishes the functional differences between proximal dendrites and distal dendrites, which receive differential inputs from the mossy fibers and the perforant pathways, respectively.

Sooyun Kim
Segundo J Guzman
Peter Jonas
Research04 Mar 2012
Nature Neuroscience

Volume: 15, P: 600-606
Parvalbumin⁺ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus

GABAergic interneurons are known to provide inhibition to allow computational function of neuronal network. Here, Espinoza and colleagues show that connectivity of granule cells and interneurons in the dentate gyrus of mouse hippocampus are consistent with the circuit architecture capable of performing a winners-take-all mechanism.

Claudia Espinoza
Segundo Jose Guzman
Peter Jonas
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-10

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Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids

Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons

Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus

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Parvalbumin⁺ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus