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Control of liquid-based materials is important for developing materials based on these, but topological flexibility is limited. Here, the authors report a method for digital fabrication of slippery objects with solid-liquid composite interfaces and geometric design freedom.

A hydrogel matrix fabricated by cryo-photocrosslinking enables the direct, scalable isolation of extracellular vesicles from diverse biofluids without preprocessing, allowing for in-gel preservation for long-term storage and biomedical applications.

A challenge in making a flexible mold stamp using roll-to-roll nanoimprint lithography is to increase area while minimizing perceptible seams. Here, based on Fourier spectral analysis of moiré patterns resulting from superposed identical patterns, a method that enables the fabrication of scalable, quasi-seamless functional surfaces without the use of alignment marks is proposed.

Holographic displays that are both compact and produce realistic holograms without eyestrain are still difficult to realize. Here the authors implement a steering-backlight unit and a holographic video processor to produce a realistic holographic display in a slim panel.

The fabrication of organic photovoltaic modules usually relies on patterning techniques which limit their efficiencies. Here, the authors propose a module structure that avoids the patterning steps, and use doctor-blade printing and slot-die coating to fabricate large-area modules reaching 7.5% efficiencies.

Engineered biofilms have applications in biorefineries. Here, Honget al. engineer bacteria to produce a combination of dispersal proteins and quorum sensing factors, and show that one dispersing bacterium can eliminate a biofilm formed by a colonizing bacterium.

The mechanism behind the severely cold winters experienced by the mid-latitudes of the Northern Hemisphere in recent years is not fully understood. Here, the authors combine observational analyses and model experiments to reveal a dynamic connection between Arctic sea-ice cover and the polar stratosphere.

Acquiring subcellular-level three-dimensional (3D) tissue structures efficiently without damaging the tissue remains challenging in histopathology. Here, the authors integrate holotomography with deep learning to generate 3D virtual H&E staining images from label-free thick cancer tissues, and apply this approach to colon and gastric cancer samples.

There has been impressive progress in the development of perovskite solar cells in recent years, but the best performing systems tend to be fabricated on glass surfaces. Here, the authors present a cell built on a polymer substrate, allowing flexibility whilst maintaining high efficiency.

Geometric confinement on arbitrary substrates promotes, without epitaxial seeding, the layer-by-layer growth of two-dimensional single-crystal monolayers and bilayers of transition metal dichalcogenides.

The integration of flexible electronics with conventional devices has been hampered by the lack of suitable soldering techniques able to withstand stretching. Jeonget al. use a porous substrate to fabricate biocompatible, stretchable electronics that can be interfaced with commercial components.

Clearance of macromolecules from the cerebrospinal fluid in mice takes place via meningeal lymphatic vessels at the base of the skull; both drainage and the integrity of these vessels deteriorate with age.

We report full-colour, vertically stacked µLEDs that achieve exceptionally high array density (5,100 pixels per inch) and small size (4 µm) via a 2D material-based layer transfer technique, allowing the creation of full-colour µLED displays for augmented and virtual reality.

Magnetoelectric materials combine ferroelectric and magnetic properties through a coupling of the spin and lattice degrees of freedom. Here, magnetoelectric bismuth ferrite is found to simultaneously undergo both a magnetic and a ferroelectric transition at the same temperature.

Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.

The authors develop a deep learning-based incoherent holographic camera system in order to deliver visually enhanced holograms in real-time. The neural network filters the noise in the captured holograms, and by integrating a holographic camera and a display, they demonstrate a holographic streaming system.

Achromatic beam deflector eliminates chromatic aberrations in dynamic beam steering using color-selective retarders and liquid crystal phase arrays, enabling independent control of RGB wavelengths for display applications.

Transfer printing of a quantum dot–ZnO film with a surface-functionalized viscoelastic stamp enables the realization of RGB QLED pixels with a resolution of 2,500 pixels per inch and a peak external quantum efficiency of 23.3% for green-emitting devices.

Here the authors show that BTLA on effector T cells interacts with HVEM on other immunosuppressive cells in the tumor microenvironment. The authors also present evidence that overcoming this checkpoint can ehance CAR T functionality.

Predicting response to cancer immunotherapy is still a challenge. Here, the authors show that their method of predicting MHC-binding peptides, combined with profiling anti-immunogenic mutations, can better predict the clinical benefit of immunotherapy.

Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.

Multiple alternating layers of two-dimensional materials and epilayers are grown on III–N and III–V substrates in a single growth run. Then, each epilayer is harvested by mechanical exfoliation, producing multiple freestanding membranes from a single wafer.

Although wireless optogenetic technologies enable brain circuit investigation in freely moving animals, existing devices have limited their full potential, requiring special power setups. Here, the authors report fully implantable optogenetic systems that allow intervention-free wireless charging and controls for operation in any environment.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Up to 20% of bacterial genomes are made up of cryptic prophages, but their function is relatively unknown. In this study, the authors demonstrate that prophages influence the response of the host cell to stress and provide a competitive growth advantage in the presence of antibiotics.

Little is known about people’s preferred responses to norm violations across countries. Here, in a study of 57 countries, the authors highlight cultural similarities and differences in people’s perception of the appropriateness of norm violations.

Cell-free protein synthesis allows for producing proteins without the need of a host organism, thus sparing the researcher experimental hassle. Here, the authors developed a cell-free synthesis method that enables incorporating non-standard amino acids in the product.

The toxin-antitoxin pair MqsR and MqsA are linked to biofilm formation, quorum sensing and motility, but their specific role in these and other cellular processes is unclear. The demonstration that MqsA directly represses transcription of rpoS, encoding the master regulator of the stress response, provides a unifying explanation.

Non-standard amino acids are incorporated into proteins at large numbers of sites using evolved translation components in recoded bacteria.

Expanding the bacterial toxin-antitoxin system classes to a fifth class, GhoST was found to be involved in maintenance of persister cells, dormant cells that are tolerant of antibiotics. GhoS is the antitoxin, an endoribonuclease that cleaves the toxin mRNA ghoT, whose gene product is a membrane-lytic protein.

Human neural stem cells from the subventricular zone are identified as the cells of origin that contain the driver mutations for glioblastomas.