SIRT1 is a deacetylase that is negatively regulated by binding to DBC1. Here Park et al.show that DNA damage-induced SUMO2/3 conjugation of DBC1 promotes the SIRT1–DBC1 interaction, leading to an increase in acetylated p53 and induction of apoptosis.
- Jong Ho Park
- Seong Won Lee
- Chin Ha Chung