Nature Search

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

Acute liver failure arises from rapid cell death and impaired liver regeneration. Here, the authors show that scalable, high-purity engineered extracellular vesicles derived from stem cells promote the clearance of dying hepatocytes and drive liver repair through in vivo macrophage reprogramming.

Seohyun Kim
Yoon Kyoung Kim
In-San Kim
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

Acrolein, a byproduct of polyamine metabolism and chemotherapeutic agents, is also found in cigarette smoke. Here the authors report that acrolein mediates spermine-induced ferroptosis, while in ferroptosis-resistant cancer cells, acrolein suppresses necroptosis by inhibiting the oligomerization of MLKL, contributing to chemotherapy resistance.

Hyun Bae
Seonghyun Moon
Rajendra Karki
ResearchOpen Access27 May 2025
Nature Communications

Volume: 16, P: 1-17
Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.

Hyunji Lee
Seonghyun Lee
Jin-Soo Kim
ResearchOpen Access19 Feb 2021
Nature Communications

Volume: 12, P: 1-6
Chloroplast and mitochondrial DNA editing in plants

This study showed efficient base editing of mitochondria and chloroplast genomes in both lettuce and rapeseed by DddA-derived cytosine base editors (DdCBEs), and DNA-free editing in chloroplasts by delivering DdCBE mRNA to protoplasts, which avoids off-target effects.

Beum-Chang Kang
Su-Ji Bae
Jin-Soo Kim
ResearchOpen Access01 Jul 2021
Nature Plants

Volume: 7, P: 899-905
SARS-CoV-2 M^pro responds to oxidation by forming disulfide and NOS/SONOS bonds

The main protease, a key enzyme of SARS-CoV-2, can protect itself from oxidative damage. Here, Reinke, Schubert, and colleagues used XFEL radiation to image the enzyme, revealing the disulfide and NOS/SONOS bonds that form in response to oxygen.

Patrick Y. A. Reinke
Robin Schubert
Thomas J. Lane
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-10
A smart insole system capable of identifying proper heel raise posture for chronic ankle instability rehabilitation

Jaewook Kim
Seonghyun Kang
Seung-Jong Kim
ResearchOpen Access24 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors

Off-target activity of DddA-derived base editors is minimized through protein engineering.

Seonghyun Lee
Hyunji Lee
Jin-Soo Kim
ResearchOpen Access13 Oct 2022
Nature Biotechnology

Volume: 41, P: 378-386
Feasibility of a new bicycle ergometer with adjustable pedaling configuration for personalized lower limb rehabilitation

Seonghyun Kang
Jaewook Kim
Seung-Jong Kim
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
Adhesive Leaf Created by a Corona Discharge

Wonseok Lee
Jongsang Son
Dae Sung Yoon
ResearchOpen Access29 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice

Sanghun Kim
Seul Gi Park
Hyunji Lee
ResearchOpen Access01 Nov 2024
Experimental & Molecular Medicine

Volume: 56, P: 2395-2408
Assessing the impact of mRNA vaccination in chronic inflammatory murine model

Seonghyun Lee
Jisun Lee
Jae-Hwan Nam
ResearchOpen Access15 Feb 2024
npj Vaccines

Volume: 9, P: 1-12
Investigation with able-bodied subjects suggests Myosuit may potentially serve as a stair ascent training robot

Jaewook Kim
Yekwang Kim
Seung-Jong Kim
ResearchOpen Access29 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Truncated TALE-FP as DNA Staining Dye in a High-salt Buffer

Eunji Shin
Woojung Kim
Kyubong Jo
ResearchOpen Access20 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation

Jae Hee Shin
SeongHyun Park
Hyuk Choi
ResearchOpen Access27 May 2022
Scientific Reports

Volume: 12, P: 1-11

Search

Filter By:

Search

Quick links