Barrett, Herzog, and Aminzadeh-Gohari et al. demonstrate that tissue-specific epigenetic DNA methylation signatures define field cancerization and can predict cancer formation, even from distant sources. Mifepristone reduced mammary gland cancer risk in mice by over 50%, with this effect mirrored in changes to cervical DNA methylation patterns.
- James E. Barrett
- Chiara Maria Herzog
- Martin Widschwendter
